Elevated blood pressure is not associated with accelerated glomerular filtration rate decline in the general non-diabetic middle-aged population

Kidney Int. 2016 Aug;90(2):404-410. doi: 10.1016/j.kint.2016.03.021. Epub 2016 May 14.


Although hypertension is a risk factor for end-stage renal disease, this complication develops in only a minority of hypertensive patients. Whether non-malignant hypertension itself is sufficient to cause reduced glomerular filtration rate (GFR) is unclear. Therefore, we investigated whether elevated blood pressure (BP) was associated with accelerated GFR decline in the general population. The study was based on the Renal Iohexol Clearance Survey in Tromsø 6 (RENIS-T6), which included a representative sample of 1594 individuals aged 50 to 62 years from the general population without baseline diabetes or kidney or cardiovascular disease. GFR was measured as iohexol clearance at baseline and follow-up after a median observation time of 5.6 years. BP was measured according to a standardized procedure. The mean (SD) GFR decline rate was 0.95 (2.23) ml/min/yr. In multivariable adjusted linear mixed regressions with either baseline systolic or diastolic BP as the independent variable, there were no statistically significant associations with GFR decline. Thus, elevated BP is not associated with accelerated mean GFR decline in the general middle-aged population. Hence, additional genetic and environmental factors are probably necessary for elevated BP to develop manifest chronic kidney disease in some individuals.

Keywords: cardiovascular disease; chronic kidney disease; hyperfiltration; obesity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blood Pressure*
  • Female
  • Follow-Up Studies
  • Glomerular Filtration Rate*
  • Humans
  • Hypertension / complications*
  • Iohexol / analysis
  • Iohexol / metabolism
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Renal Elimination
  • Renal Insufficiency, Chronic / etiology
  • Risk Factors


  • Iohexol