Chronic administration of Angelica sinensis polysaccharide effectively improves fatty liver and glucose homeostasis in high-fat diet-fed mice

Sci Rep. 2016 May 18:6:26229. doi: 10.1038/srep26229.


This study aimed to investigate the therapeutic effects of Angelica sinensis polysaccharide (ASP), an active component derived from a water extract of Angelica sinensis, in high-fat diet (HFD)-fed BALB/c mice. The potential mechanisms underlying the activity of this compound were also considered. Specifically, serum and hepatic biochemical parameters were evaluated, and key proteins involved in the lipid/glucose metabolism were analyzed. Long-term feeding with a HFD induced severe fatty liver and hyperglycemia. Histological examination clearly showed that ASP reduced lipid accumulation in the liver and attenuated hepatic steatosis in HFD-fed mice. In addition, ASP markedly alleviated serum and liver lipid disorders and fatty liver via the upregulation of PPARγ expression and the activation of adiponectin-SIRT1-AMPK signaling. Furthermore, ASP also significantly relieved severe oxidative stress, demonstrating that ASP might attenuate nonalcoholic fatty liver disease via a "two-hit" mechanism. In addition, ASP reduced blood glucose levels and ameliorated insulin resistance via the regulation of related metabolic enzymes and by activating the PI3K/Akt pathway in HFD-fed mice. Our findings revealed that ASP might be used as an alternative dietary supplement or health care product to ameliorate metabolic syndrome in populations that consistently consume HFDs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angelica sinensis / chemistry*
  • Animals
  • Blood Glucose / analysis
  • Diet, High-Fat
  • Dyslipidemias / drug therapy
  • Fatty Liver / drug therapy*
  • Fatty Liver / pathology
  • Fatty Liver / physiopathology*
  • Gastrointestinal Agents / administration & dosage*
  • Gastrointestinal Agents / isolation & purification
  • Glucose / metabolism*
  • Homeostasis*
  • Liver / pathology
  • Mice, Inbred BALB C
  • Plant Extracts / administration & dosage
  • Plant Extracts / isolation & purification
  • Polysaccharides / administration & dosage*
  • Polysaccharides / isolation & purification
  • Treatment Outcome


  • Blood Glucose
  • Gastrointestinal Agents
  • Plant Extracts
  • Polysaccharides
  • Glucose