Creating biomaterials with spatially organized functionality

Exp Biol Med (Maywood). 2016 May;241(10):1025-32. doi: 10.1177/1535370216648023. Epub 2016 May 4.


Biomaterials for tissue engineering provide scaffolds to support cells and guide tissue regeneration. Despite significant advances in biomaterials design and fabrication techniques, engineered tissue constructs remain functionally inferior to native tissues. This is largely due to the inability to recreate the complex and dynamic hierarchical organization of the extracellular matrix components, which is intimately linked to a tissue's biological function. This review discusses current state-of-the-art strategies to control the spatial presentation of physical and biochemical cues within a biomaterial to recapitulate native tissue organization and function.

Keywords: Biomaterials; biomedical; extracellular matrix; regenerative medicine; tissue engineering; translational.

Publication types

  • Review

MeSH terms

  • Animals
  • Biocompatible Materials / chemistry
  • Biocompatible Materials / isolation & purification
  • Biocompatible Materials / pharmacology*
  • Chemical Phenomena
  • Guided Tissue Regeneration / methods
  • Humans
  • Tissue Engineering / methods*


  • Biocompatible Materials