Hepatitis B in Pregnancy

Clin Infect Dis. 2016 Jun 1;62 Suppl 4(Suppl 4):S314-7. doi: 10.1093/cid/ciw092.


Chronic hepatitis B virus (HBV) infection is estimated to affect >350 million people worldwide and represents a significant cause of morbidity and mortality related to cirrhosis and hepatocellular carcinoma. Mother-to-child transmission (MTCT) of HBV remains an important source of incident cases of HBV. Current barriers to eradication of incident HBV infections via MTCT include underutilization of immunoprophylaxis with hepatitis B vaccination and hepatitis B immune globulin in certain endemic regions as well as failure of immunoprophylaxis.

Keywords: hepatitis B; perinatal transmission; pregnancy; vaccination HBIG.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Female
  • Hepatitis B Vaccines
  • Hepatitis B virus
  • Hepatitis B* / prevention & control
  • Hepatitis B* / transmission
  • Hepatitis B* / virology
  • Humans
  • Infectious Disease Transmission, Vertical* / prevention & control
  • Infectious Disease Transmission, Vertical* / statistics & numerical data
  • Pregnancy
  • Pregnancy Complications, Infectious* / prevention & control
  • Pregnancy Complications, Infectious* / virology
  • Young Adult


  • Hepatitis B Vaccines