Evaluation of vitamin D metabolism in patients with bilateral sensorineural hearing loss

Am J Otol. 1989 Jan;10(1):11-3.


The possible role of vitamin D in hearing impairment was investigated by the measurement of three metabolites of vitamin D in 28 patients with bilateral sensorineural hearing loss (BSNHL). Twenty-three of 28 patients showed a significantly decreased level of 1,25-dihydroxyvitamin D3, with a normal value of 25-hydroxyvitamin D3. In addition to experimental and clinical reports regarding vitamin D deficiency, the present study suggests that vitamin D deficiency is one of the etiologies of BSNHL, through the calcium metabolism and microcirculation in the cochlea.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Calcifediol / blood
  • Calcitriol / blood
  • Calcium / metabolism
  • Child
  • Female
  • Hearing Loss, Bilateral / etiology
  • Hearing Loss, Bilateral / metabolism
  • Hearing Loss, Sensorineural / etiology
  • Hearing Loss, Sensorineural / metabolism*
  • Humans
  • Male
  • Middle Aged
  • Vitamin D / metabolism*
  • Vitamin D Deficiency / complications


  • Vitamin D
  • Calcitriol
  • Calcifediol
  • Calcium