Antibody Response and Disease Severity in Healthcare Worker MERS Survivors

Emerg Infect Dis. 2016 Jun;22(6):1113-1115. doi: 10.3201/eid2206.160010.


We studied antibody response in 9 healthcare workers in Jeddah, Saudi Arabia, who survived Middle East respiratory syndrome, by using serial ELISA and indirect immunofluorescence assay testing. Among patients who had experienced severe pneumonia, antibody was detected for >18 months after infection. Antibody longevity was more variable in patients who had experienced milder disease.

Keywords: ELISA; IFA; Jeddah; MERS-CoV; Middle East respiratory syndrome coronavirus; Saudi Arabia; antibody; healthcare workers; immune response; indirect immunofluorescence assay; viruses.

MeSH terms

  • Adult
  • Antibodies, Bacterial / immunology*
  • Coronavirus Infections / diagnosis
  • Coronavirus Infections / epidemiology*
  • Coronavirus Infections / immunology*
  • Coronavirus Infections / virology
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Health Personnel*
  • Humans
  • Male
  • Middle Aged
  • Middle East Respiratory Syndrome Coronavirus / genetics
  • Middle East Respiratory Syndrome Coronavirus / immunology*
  • Saudi Arabia / epidemiology
  • Severity of Illness Index
  • Survivors*
  • Virus Shedding


  • Antibodies, Bacterial