Efficiency of Ozone Therapy in a Rat Model of Experimental Uveitis

Ocul Immunol Inflamm. 2017 Oct;25(5):695-700. doi: 10.3109/09273948.2016.1161057. Epub 2016 May 18.


Purpose: To investigate efficiency of ozone therapy in uveitis.

Methods: A total of 24 albino Wistar rats were randomly assigned to four groups (n = 6); (a) control group; (b) sham group; (c) infliximab treatment group; (d) ozone therapy group. Vitreous haze scores of all groups were evaluated. Vitreous cytokine levels (TNF-α, IL-1, IL-6) measured by ELISA and eyes were enucleated for histopathologic examination.

Results: According to vitreous haze scores, there was statistically significant inflammation in Group (b) compared with Group (a), and there was less inflammation in infliximab and ozone groups compared with Group (b) (p < 0.05). Cytokine levels in infliximab and ozone groups were lower but not statistically significant when compared with Group (b) (p > 0.05). There was significantly less inflammation in histopathologic examination in treatment groups when compared with the sham group (p < 0.05).

Conclusions: Clinical and histopathologic examination results indicate that systemic application of ozone may be efficient in the treatment of uveitis.

Keywords: Experimental uveitis; IL-1; IL-6; TNF-α; ozone therapy.

MeSH terms

  • Animals
  • Antirheumatic Agents / therapeutic use
  • Disease Models, Animal*
  • Enzyme-Linked Immunosorbent Assay
  • Infliximab / therapeutic use
  • Interleukin-1 / metabolism
  • Interleukin-6 / metabolism
  • Oxidants, Photochemical / therapeutic use*
  • Ozone / therapeutic use*
  • Rats
  • Rats, Wistar
  • Treatment Outcome
  • Tumor Necrosis Factor-alpha / metabolism
  • Uveitis / drug therapy*
  • Uveitis / metabolism
  • Vitreous Body / metabolism


  • Antirheumatic Agents
  • Interleukin-1
  • Interleukin-6
  • Oxidants, Photochemical
  • Tumor Necrosis Factor-alpha
  • Ozone
  • Infliximab