Homing in on the Sweet Side of Immune Checkpoint Biology

Steven R Barthel; Tobias Schatton

doi:10.1016/j.immuni.2016.05.003

Homing in on the Sweet Side of Immune Checkpoint Biology

Immunity. 2016 May 17;44(5):1083-5. doi: 10.1016/j.immuni.2016.05.003.

Authors

Steven R Barthel¹, Tobias Schatton²

Affiliations

¹ Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
² Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: tschatton@bwh.harvard.edu.

PMID: 27192573
DOI: 10.1016/j.immuni.2016.05.003

Abstract

P-selectin glycoprotein ligand-1 (PSGL-1) and its glycostructural determinants facilitate responses to infection and cancer by promoting immune effector-cell trafficking into inflamed tissue. In this issue of Immunity, Tinoco et al. (2016) report homing-independent functions of PSGL-1 in immune checkpoint regulation and T cell effector activity, in models of chronic viral infection and melanoma.

Publication types

Comment

MeSH terms

Cell Cycle Checkpoints
Cell Movement / immunology
Humans
Membrane Glycoproteins / chemistry*
P-Selectin / immunology
T-Lymphocytes / immunology*

Substances

Membrane Glycoproteins
P-Selectin
P-selectin ligand protein