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. 2016 Jun 3;18(11):2688-91.
doi: 10.1021/acs.orglett.6b01158. Epub 2016 May 19.

Gymnopeptides A and B, Cyclic Octadecapeptides from the Mushroom Gymnopus fusipes

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Gymnopeptides A and B, Cyclic Octadecapeptides from the Mushroom Gymnopus fusipes

Attila Ványolós et al. Org Lett. .

Abstract

Mycochemical study of the mushroom Gymnopus fusipes led to the discovery of two new cyclopeptides. The two compounds, named as gymnopeptides A and B, are unprecedented highly N-methylated cyclic octadecapeptides. Detailed spectroscopic studies, Marfey's analysis, and a preliminary molecular modeling study suggested that both are natural cyclic β hairpins. The isolated compounds exhibited striking antiproliferative activity on several human cancer cell lines, with nanomolar IC50 values.

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