Effects of theta-rhythm transcranial alternating current stimulation (4.5 Hz-tACS) in patients with clozapine-resistant negative symptoms of schizophrenia: a case series

J Neural Transm (Vienna). 2016 Oct;123(10):1213-7. doi: 10.1007/s00702-016-1574-x. Epub 2016 May 19.

Abstract

Our aim was to assess the efficacy and safety of theta-rhythm transcranial Alternating Current Stimulation (4.5 Hz-tACS) in patients with clozapine-resistant symptoms of schizophrenia. In an open case series, 3 patients received 20 sessions of 4.5 Hz-tACS (20 min, 2 mA) applied over the dorsolateral prefrontal cortex. The patients exhibited a decrease of negative symptoms (-10 %), general symptoms (-18 %) and an improvement of insight into the illness (-25 %). 4.5 Hz-tACS might be a suitable alternative treatment for clozapine-resistant symptoms of schizophrenia.

Keywords: DLPFC; Insight; Prefrontal cortex; Schizophrenia; tACS; tDCS.

MeSH terms

  • Adult
  • Antipsychotic Agents / adverse effects
  • Clozapine / adverse effects
  • Electroencephalography
  • Female
  • Humans
  • Male
  • Prefrontal Cortex / physiology*
  • Psychiatric Status Rating Scales
  • Schizophrenia / therapy*
  • Theta Rhythm / physiology*
  • Transcranial Direct Current Stimulation / methods*
  • Young Adult

Substances

  • Antipsychotic Agents
  • Clozapine