Liver Transplantation for Alcohol-Related Liver Disease

J Clin Exp Hepatol. 2016 Mar;6(1):47-53. doi: 10.1016/j.jceh.2016.02.001. Epub 2016 Feb 27.

Abstract

Alcoholic liver disease (ALD) is a common indication for liver transplantation. It is a much debated indication for deceased donor liver transplantation due to organ shortage and potential of alcohol relapse after liver transplantation. A six-month abstinence before liver transplantation is required at most centers to decrease chances of alcohol relapse after liver transplantation. However, this rule is not relevant for patients with severe alcoholic hepatitis or severely decompensated patients who are unlikely to survive till 6 months. Long-term care of these patients after liver transplantation includes assessment of relapse, smoking, and surveillance of de novo malignancies. Current review discusses role of abstinence, factors affecting alcohol relapse, liver transplantation for alcoholic hepatitis, role of living donor liver transplantation, and long-term care of ALD patients who undergo liver transplantation.

Keywords: ALD, alcoholic liver disease; CDT, carbohydrate-deficient transferring; GGT, gamma-glutamyltranspeptidase; HRAR, High Risk Alcoholism Relapse score; LDLT, living donor liver transplantation; MELD, Model for End-Stage Liver Disease score; alcoholic liver disease; liver transplantation; outcome; relapse.

Publication types

  • Review