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Review
. 2016 May 18;4:19.
doi: 10.1186/s40337-016-0106-2. eCollection 2016.

Neurobiological Model of the Persistence of Anorexia Nervosa

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Free PMC article
Review

Neurobiological Model of the Persistence of Anorexia Nervosa

Joanna E Steinglass et al. J Eat Disord. .
Free PMC article

Abstract

Anorexia Nervosa (AN) is characterized by the maintenance of an undernourished, or starved, state. Persistent restrictive eating, or the recurrent intake of a diet that is inadequate to sustain a healthy weight, is the central behavior maintaining AN. To understand this disturbance, we need to understand the neural mechanisms that allow or promote the persistent choice of inadequate caloric intake. While a range of neural disturbances have been reported in AN, abnormalities in systems relevant to reward processing and the development of habit systems have been consistently described in both structural and functional neuroimaging studies. Most recently, brain and behavior have been directly examined by investigating the neural underpinnings of restrictive food choice. These recent data suggest that, among individuals with AN, dorsal frontostriatal circuits play a greater role in guiding decisions regarding what to eat than among healthy individuals. This line of research attempts to leverage advances in the field of cognitive neuroscience to further our understanding of persistent maladaptive choices of individuals with AN, in the hope that such advances will help in the development of novel treatments for this potentially fatal disorder.

Keywords: Anorexia nervosa; Cognitive neuroscience; Eating behavior; Habit systems; Reward systems.

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References

    1. Hudson JI, Hiripi E, Pope HG, Jr, Kessler RC. The prevalence and correlates of eating disorders in the National Comorbidity Survey Replication. Biol Psychiatry. 2007;61(3):348–58. doi: 10.1016/j.biopsych.2006.03.040. - DOI - PMC - PubMed
    1. Gard MC, Freeman CP. The dismantling of a myth: a review of eating disorders and socioeconomic status. Int J Eat Disord. 1996;20(1):1–12. doi: 10.1002/(SICI)1098-108X(199607)20:1<1::AID-EAT1>3.0.CO;2-M. - DOI - PubMed
    1. APA . Diagnostic and Statistical Manual of Mental Disorders. 4. Washington: American Psychiatric Association Press; 2000.
    1. Herpertz-Dahlmann B. Adolescent eating disorders: update on definitions, symptomatology, epidemiology, and comorbidity. Child Adolesc Psychiatr Clin N Am. 2015;24(1):177–96. doi: 10.1016/j.chc.2014.08.003. - DOI - PubMed
    1. Swanson SA, Crow SJ, Le Grange D, Swendsen J, Merikangas KR. Prevalence and correlates of eating disorders in adolescents. Results from the national comorbidity survey replication adolescent supplement. Arch Gen Psychiatry. 2011;68(7):714–23. doi: 10.1001/archgenpsychiatry.2011.22. - DOI - PMC - PubMed

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