ICSI outcomes in men undergoing TESE for azoospermia and impact of maternal age

Andrologia. 2017 Mar;49(2). doi: 10.1111/and.12617. Epub 2016 May 20.


This retrospective study compared clinical outcomes in men with obstructive and nonobstructive azoospermia after ICSI following testicular sperm extraction and the influence of maternal age. Fertilisation rates, embryo quality, pregnancy rates, miscarriage rates and live birth rates were evaluated. Men with obstructive azoospermia (OA) had significantly higher rates of diploid fertilisation and clinical pregnancy than men with nonobstructive azoospermia (NOA), but miscarriage rates and live birth rates were not significantly different. The higher rates of fertilisation, embryo quality and clinical pregnancy in men with OA were statistically significant when their female partners were <35 years but results were similar in both groups when female partners ≥35 years. Although the OA group had better overall quality embryos than the NOA group when maternal age was <35 years, embryologists can select the morphologically better embryos for transfer, eliminating the effect of embryo quality differences present in these two groups. Understanding more about factors that affect TESE/ICSI outcomes will not only help us predict patients' outcomes but it can help us educate and better counsel our patients.

Keywords: ICSI; TESE; Azoospermia; pregnancy.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Azoospermia / therapy*
  • Birth Rate
  • Female
  • Humans
  • Male
  • Maternal Age*
  • Middle Aged
  • Pregnancy
  • Pregnancy Rate
  • Retrospective Studies
  • Sperm Injections, Intracytoplasmic / methods
  • Sperm Injections, Intracytoplasmic / statistics & numerical data*
  • Sperm Retrieval*
  • Treatment Outcome