A reversible B-A transition of DNA duplexes induced by synthetic cationic copolymers

Chem Commun (Camb). 2016 Jun 14;52(47):7446-9. doi: 10.1039/c6cc02237e. Epub 2016 May 20.

Abstract

Although the B-form duplex is the canonical DNA structure, the A-form duplex plays critical roles in controlling gene expression. Here, reversible B-A transitions of DNA duplexes were induced by synthetic cationic and anionic polymers. Thermodynamic analysis demonstrated that the B-A transition was regulated by the dehydration of the DNA duplex caused by polymer binding.

MeSH terms

  • Cations / chemical synthesis
  • Cations / chemistry
  • DNA / chemistry*
  • Polymers / chemical synthesis*
  • Polymers / chemistry
  • Thermodynamics

Substances

  • Cations
  • Polymers
  • DNA