Hypoalbuminaemia at admission predicts the poor outcomes in critically ill children

Anaesthesiol Intensive Ther. 2016;48(3):158-61. doi: 10.5603/AIT.a2016.0028. Epub 2016 May 20.

Abstract

Background: Hypoalbuminaemia at admission is a common finding in patients admitted to the Paediatric Intensive Care Unit (PICU) and it is thought that this may predict morbidity and mortality.

Methods: A retrospective study was conducted in the tertiary hospital. The medical records of critically ill children were reviewed. The data were analyzed for the prevalence of hypoalbuminaemia and outcomes.

Results: Two hundred and two patients were included in the analysis. The incidence of hypoalbuminaemia at admission was 57.9%. These patients had a mortality rate 4 times greater (adjusted odds ratio 3.8; 95% CI: 1.4-10.0), a longer length of PICU stay (8.6 vs. 6.7 days, P = 0.04) and a longer period on a ventilator (5.9 vs. 3.9 days, P = 0.04) than patients with normal albumin levels.

Conclusions: Hypoalbuminaemia at admission was a predictive factor of poor outcome in critically ill children. It is associated with a higher mortality, a longer length of stay in the PICU, as well as longer ventilator use.

Keywords: clinical outcomes; critically ill children; hypoalbuminaemia; prediction factor.

MeSH terms

  • Child
  • Child, Preschool
  • Critical Care / methods
  • Critical Illness / mortality
  • Critical Illness / therapy*
  • Female
  • Hospitalization
  • Humans
  • Hypoalbuminemia / blood*
  • Hypoalbuminemia / mortality
  • Infant
  • Intensive Care Units, Pediatric
  • Length of Stay
  • Male
  • Predictive Value of Tests
  • Prognosis
  • Respiration, Artificial / statistics & numerical data
  • Retrospective Studies
  • Survival Analysis
  • Treatment Outcome