Case report of eosinophilia induced by quetiapine

Shanghai Arch Psychiatry. 2015 Dec 25;27(6):374-7. doi: 10.3969/j.issn.1002-0829.215005.


An increase in the concentration of eosinophils in blood may lead to endocarditis, myocarditis, and pericarditis. When the absolute eosinophil count increases beyond 1.5 x 10(9)/L, myocardial damage and even death can occur. This case report describes a 47-year-old male with an alcohol-induced psychotic disorder who developed eosinophilia 4 weeks after starting treatment with quetiapine 50-200 mg/d. His maximum recorded absolute eosinophil count was 7.63 x 10(9)/L (normal range < 0.5 x 10(9)/L), but the level returned to normal over a 4-week period after stopping quetiapine and no myocardial damage was observed. This patient's dramatic eosinophilia did not have any associated clinical symptoms; it was only identified as part of a routine blood test a few weeks after starting quetiapine. This is a reminder that all clinicians who treat patients with antipsychotic medications must be vigilant about the occurrence of such rare but life-threatening adverse events.

血液中嗜酸性粒细胞浓度增加可能会导致心内膜炎、心肌炎乃至心包炎。当嗜酸性粒细胞计数超过1.5×109/L 时,心肌会受损,甚至会发生死亡。本文报告的病例关于一位患酒精所致精神障碍的47 岁男性,经喹硫平50 mg/d~200 mg/d 的剂量治疗4 周后发生嗜酸性粒细胞增多症。患者的嗜酸性粒细胞高达 7.63x109/ L(正常范围< 0.5×109/L),但停用喹硫平 4 周后恢复正常,没有心肌受损的表现。该患者突发嗜酸性粒细胞增多症,并无任何相关的临床症状,只是在服用喹硫平数周后常规血液学检查时才发现的。 这提醒所有医生在使用抗精神病药物治疗患者时要警惕这种罕见但会危及生命的不良反应。.

中文全文: 本文全文中文版从2016年04月25日起在10.3969/j.issn.1002-0829.215005可供免费阅览下载.

Keywords: China; case report; eosinophilia; quetiapine.

Publication types

  • Case Reports

Grants and funding

No funding was provided for preparing this case report.