The Structure and Dynamics of Higher-Order Assemblies: Amyloids, Signalosomes, and Granules

Cell. 2016 May 19;165(5):1055-1066. doi: 10.1016/j.cell.2016.05.004.


We here attempt to achieve an integrated understanding of the structure and dynamics of a number of higher-order assemblies, including amyloids, various kinds of signalosomes, and cellular granules. We propose that the synergy between folded domains, linear motifs, and intrinsically disordered regions regulates the formation and intrinsic fuzziness of all higher-order assemblies, creating a structural and dynamic continuum. We describe how such regulatory mechanisms could be influenced under pathological conditions.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amyloid / chemistry
  • Amyloid / metabolism
  • Humans
  • Multiprotein Complexes / chemistry
  • Organelles / chemistry*
  • Organelles / metabolism*
  • Prions / chemistry
  • Prions / metabolism
  • Protein Structure, Quaternary
  • Signal Transduction


  • Amyloid
  • Multiprotein Complexes
  • Prions