Intraperitoneal P-32 after negative second-look laparotomy in ovarian carcinoma

Cancer. 1989 Jun 15;63(12):2434-7. doi: 10.1002/1097-0142(19890615)63:12<2434::aid-cncr2820631211>;2-b.


Thirty-one patients underwent a negative second-look laparotomy between 1976 and 1986. Fourteen patients received intraperitoneal chromic phosphate (P-32) after a negative second-look laparotomy. There has been no local recurrence (zero of 14) and no deaths attributable to recurrent disease. Local control and disease-free survival are 100%, with a minimum follow-up of 2 years and a mean follow-up of 4 years. Seventeen patients received no further therapy because of patient refusal, poor diffusion, or other contraindications to P-32 installation. Four of 17 patients undergoing negative second-look procedures without the addition of P-32 have subsequently recurred. This difference is highly suggestive (P = .076). There have been no major complications with the addition of P-32. The use of intraperitoneal P-32 after negative second-look laparotomies on ovarian carcinoma is well tolerated and effective in preventing recurrence.

MeSH terms

  • Female
  • Follow-Up Studies
  • Humans
  • Infusions, Parenteral
  • Laparotomy
  • Neoplasm Recurrence, Local / prevention & control
  • Ovarian Neoplasms / mortality
  • Ovarian Neoplasms / radiotherapy*
  • Phosphorus Radioisotopes / administration & dosage*
  • Reoperation


  • Phosphorus Radioisotopes