Context matters in MLL-AF9-driven leukemias

Blood. 2016 May 12;127(19):2268-9. doi: 10.1182/blood-2016-03-704338.

Abstract

In this issue of Blood, Man et al demonstrate that the transforming activity of the leukemic fusion oncogene MLL-AF9 is regulated by inhibitor of DNA binding 1 (Id1), a dominant-negative regulator of E protein transcription factors.

Publication types

  • Comment

MeSH terms

  • Histone-Lysine N-Methyltransferase
  • Humans
  • Leukemia*
  • Myeloid-Lymphoid Leukemia Protein*
  • Oncogene Proteins, Fusion

Substances

  • Oncogene Proteins, Fusion
  • Myeloid-Lymphoid Leukemia Protein
  • Histone-Lysine N-Methyltransferase