Complex heatmaps reveal patterns and correlations in multidimensional genomic data

Bioinformatics. 2016 Sep 15;32(18):2847-9. doi: 10.1093/bioinformatics/btw313. Epub 2016 May 20.


Parallel heatmaps with carefully designed annotation graphics are powerful for efficient visualization of patterns and relationships among high dimensional genomic data. Here we present the ComplexHeatmap package that provides rich functionalities for customizing heatmaps, arranging multiple parallel heatmaps and including user-defined annotation graphics. We demonstrate the power of ComplexHeatmap to easily reveal patterns and correlations among multiple sources of information with four real-world datasets.

Availability and implementation: The ComplexHeatmap package and documentation are freely available from the Bioconductor project:


Supplementary information: Supplementary data are available at Bioinformatics online.

MeSH terms

  • Computer Graphics
  • Gene Expression
  • Genomics*
  • Humans
  • Metabolic Networks and Pathways
  • Software*