Comparing homologous microscopic sections from multiple embryos using HREM

Dev Biol. 2016 Jul 1;415(1):1-5. doi: 10.1016/j.ydbio.2016.05.011. Epub 2016 May 18.

Authors

R Mark Henkelman¹, Miriam Friedel¹, Jason P Lerch¹, Robert Wilson², Timothy Mohun²

Affiliations

¹ Mouse Imaging Centre (MICe), Hospital for Sick Children, University of Toronto, Toronto, Canada.
² The Francis Crick Institute Mill Hill Laboratory, London, UK.

Abstract

•
3D HREM embryo images can be registered.
•
Homologous microscopic sections can be obtained from multiple embryos.
•
Anatomical phenotypes can be analyzed by computer.

Publication types

Comparative Study

MeSH terms

Algorithms
Animals
Computer Simulation
Developmental Biology*
Diagnostic Imaging / methods*
Female
Image Processing, Computer-Assisted*
Imaging, Three-Dimensional / methods*
Male
Mice
Microscopy / methods
Models, Statistical
Phenotype