Overview: Global and Local Impact of Antibiotic Resistance

Infect Dis Clin North Am. 2016 Jun;30(2):313-322. doi: 10.1016/j.idc.2016.02.001.


The rapid and ongoing spread of antibiotic resistance poses a serious threat to global public health. The indiscriminant use of antibiotics in agriculture and human medicine along with increasingly connected societies has fueled the distribution of antibiotic-resistant bacteria. These factors together have led to rising numbers of infections caused by multidrug-resistant and pan-resistant bacteria, with increases in morbidity and mortality. This article summarizes the trends in antibiotic resistance, discusses the impact of antibiotic resistance on society, and reviews the use of antibiotics in agriculture. Feasible ways to tackle antibiotic resistance to avert a post-antibiotic era are suggested.

Keywords: Agriculture; Antibiotic resistance; Infections; Public health.

Publication types

  • Review

MeSH terms

  • Agriculture
  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use
  • Bacteria / drug effects
  • Bacterial Infections* / drug therapy
  • Bacterial Infections* / microbiology
  • Bacterial Infections* / prevention & control
  • Drug Resistance, Bacterial*
  • Global Health*
  • Humans
  • Public Health*
  • United States


  • Anti-Bacterial Agents