Effects of the polysaccharides extracted from Ganoderma lucidum on chemotherapy-related fatigue in mice

Int J Biol Macromol. 2016 Oct;91:905-10. doi: 10.1016/j.ijbiomac.2016.04.084. Epub 2016 May 18.


The weight-loaded swimming capability, tumor growth, survival time and biochemical markers of Ganoderma lucidum polysaccharides (GLPs) in a chemotherapy-related fatigue mouse model were tested in the present study. The results showed that the middle-dose GLPs (GLP-M) and the high-dose GLPs (GLP-H) could increase the exhausting swimming time, which was observed to decrease in the cisplatin control group(PCG) and the tumor control group (TCG).The GLP-M and the GLP-H had reduced serum levels of tumor necrosis factor-αand interleukin-6, which were up-regulated by cisplatin. Cisplatin and the presence of tumor significantly enhanced the malondialdehyde (MDA) content and inhibited the activity of superoxide dismutase (SOD) in the muscle. Administration of GLPs at a high dose decreased the levels of MDA and up-regulated the SOD activity. The high-dose GLPs+cisplatin group presented a decreased tendency of tumor volume and a lower tumor weight compared with PCG. Moreover, the mice in the GLP-M and GLP-H groups had longer survival times compared with the mice in the TCG and PCG.The levels of creatinine and serum blood urea nitrogen, which are up-regulated by cisplatin, were significantly reduced by GLP-M and GLP-H. Therefore, these results suggest that GLPs might improve chemotherapy-related fatigue via regulation of inflammatory responses, oxidative stress and reduction of nephrotoxicity.

Keywords: Chemotherapy-Related fatigue; Ganoderma lucidum polysaccharides; Mouse model.

MeSH terms

  • A549 Cells
  • Animals
  • Blood Urea Nitrogen
  • Cisplatin / adverse effects
  • Creatinine / blood
  • Drug Therapy*
  • Fatigue / blood
  • Fatigue / chemically induced*
  • Fatigue / drug therapy*
  • Interleukin-1beta / blood
  • Interleukin-6 / blood
  • Male
  • Malondialdehyde / metabolism
  • Mice, Inbred BALB C
  • Muscle, Skeletal / drug effects
  • Muscle, Skeletal / enzymology
  • Polysaccharides / therapeutic use*
  • Reishi / chemistry*
  • Superoxide Dismutase / metabolism
  • Survival Analysis
  • Swimming
  • Transforming Growth Factor alpha / blood
  • Tumor Burden / drug effects


  • Interleukin-1beta
  • Interleukin-6
  • Polysaccharides
  • Transforming Growth Factor alpha
  • Malondialdehyde
  • Creatinine
  • Superoxide Dismutase
  • Cisplatin