Glomeruloid hemangioma and POEMS syndrome

Actas Dermosifiliogr. 2017 Mar;108(2):e15-e19. doi: 10.1016/ Epub 2016 May 18.
[Article in English, Spanish]


POEMS syndrome is a paraneoplastic manifestation associated with hematopoietic disorders such as multiple myeloma and Castleman disease. POEMS is an acronym for the main clinical features of the syndrome, namely, Polyneuropathy, Organomegaly, Endocrinopathy, M protein, and Skin abnormalities. Glomeruloid hemangiomas are considered to be a specific clinical marker of POEMS syndrome. However, while they are not pathognomonic, their presence should raise suspicion of this syndrome or alert clinicians to its possible future development, as these lesions can appear years before the onset of the syndrome. We report the cases of 2 women with plasma cell dyscrasias and sudden onset of lesions with a vascular appearance and histologic findings consistent with glomeruloid hemangioma. Recognition of this vascular tumor is important for the early diagnosis of POEMS syndrome.

Keywords: Glomeruloid hemangioma; Hemangioma glomeruloide; Paraneoplastic syndrome; Polyneuropathy, Organomegaly, Endocrinopathy, M-protein, Skin abnormalities syndrome; Síndrome de Polineuropatía, Organomegalia, Endocrinopatía, M proteína, Skin abnormalities; Síndrome paraneoplásico.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Dermoscopy
  • Female
  • Hemangioma / etiology*
  • Hemangioma / pathology
  • Humans
  • Middle Aged
  • Multiple Myeloma / complications*
  • Multiple Myeloma / diagnosis
  • POEMS Syndrome / etiology*
  • POEMS Syndrome / pathology
  • Paraneoplastic Syndromes / etiology*
  • Paraneoplastic Syndromes / pathology
  • Plasmacytoma / complications*
  • Plasmacytoma / diagnostic imaging
  • Positron Emission Tomography Computed Tomography
  • Skin Neoplasms / etiology*
  • Skin Neoplasms / pathology