[Anti-obesogenic effect of apple cider vinegar in rats subjected to a high fat diet]

Ann Cardiol Angeiol (Paris). 2016 Jun;65(3):208-13. doi: 10.1016/j.ancard.2016.04.004. Epub 2016 May 18.
[Article in French]


Aim of the study: The search of new anti-obesogenic treatments based on medicinal plants without or with minimal side effects is a challenge. In this context, the present study was conducted to evaluate the anti-obesogenic effect of apple cider vinegar (ACV) in Wistar rats subjected to a high fat diet.

Materials and methods: Eighteen male Wistar rats (140±5g) were divided into 3 three equal groups. A witness group submitted to standard laboratory diet and two groups subjected to a high fat diet (cafeteria diet); one receives a daily gavage of apple cider vinegar (7mL/kg/d) for 30 days. Throughout the experiment monitoring the nutritional assessment, anthropometric and biochemical parameters is achieved.

Results: In the RCV vs RC group, we observed a highly significant decrease (P<0.001) in body weight and food intake. On the other hand, the VCP decreases very significantly different anthropometric parameters: BMI (P<0.01), chest circumference and abdominal circumference (P<0.001), decreases serum glucose levels (26.83%) and improves the serum lipid profile by reducing plasma levels of total cholesterol (34.29%), TG (51.06%), LDL-c (59.15%), VLDL (50%) and the total lipid (45.15%), and increasing HDL-c (39.39%), thus offering protection against oatherogenic risk (61.62%).

Conclusion: This preliminary study indicates that the metabolic disorders caused by high fat diet (cafeteria) are thwarted by taking apple cider vinegar which proves to have a satiating effect, antihyperlipidemic and hypoglycemic effects, and seems prevent the atherogenic risk.

Keywords: Anthropometry; Anthropométrie; Antihyperlipidemic effect; Apple cider vinegar; Cardiovascular disease; Effet hypolipémiant; Maladies cardiovasculaires; Non-drug treatments; Obesity; Obésité; Traitements non médicamenteux; Vinaigre de cidre de pomme.

MeSH terms

  • Acetic Acid / pharmacology
  • Acetic Acid / therapeutic use*
  • Animals
  • Antioxidants / pharmacology
  • Antioxidants / therapeutic use*
  • Body Weight / drug effects*
  • Diet, High-Fat
  • Disease Models, Animal
  • Male
  • Malus*
  • Obesity / drug therapy*
  • Oxidative Stress / drug effects*
  • Rats
  • Rats, Wistar
  • Treatment Outcome


  • Antioxidants
  • Acetic Acid