Environment-driven somatic mosaicism in brain disorders

Genome Med. 2016 May 23;8(1):58. doi: 10.1186/s13073-016-0317-9.


The identification of somatic mosaicism in the brain lends a new perspective to our understanding of the role of gene and environment interactions in psychiatric disease risk. Somatic mutations, such as retrotransposon insertions, that are precipitated by modern environmental factors may alter neuronal function and neurological traits, increasing the societal prevalence of mental disorders.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain Diseases / genetics*
  • Gene-Environment Interaction*
  • Genetic Predisposition to Disease
  • Humans
  • Mosaicism
  • Mutagenesis, Insertional
  • Mutation*
  • Retroelements / physiology*


  • Retroelements