The hnRNP family: insights into their role in health and disease

Hum Genet. 2016 Aug;135(8):851-67. doi: 10.1007/s00439-016-1683-5. Epub 2016 May 23.


Heterogeneous nuclear ribonucleoproteins (hnRNPs) represent a large family of RNA-binding proteins (RBPs) that contribute to multiple aspects of nucleic acid metabolism including alternative splicing, mRNA stabilization, and transcriptional and translational regulation. Many hnRNPs share general features, but differ in domain composition and functional properties. This review will discuss the current knowledge about the different hnRNP family members, focusing on their structural and functional divergence. Additionally, we will highlight their involvement in neurodegenerative diseases and cancer, and the potential to develop RNA-based therapies.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alternative Splicing / genetics
  • Heterogeneous-Nuclear Ribonucleoproteins / genetics*
  • Humans
  • Neoplasms / genetics*
  • Neoplasms / pathology
  • Neurodegenerative Diseases / genetics*
  • Neurodegenerative Diseases / pathology
  • Protein Biosynthesis
  • RNA Stability / genetics
  • RNA, Messenger / genetics
  • RNA-Binding Proteins
  • Transcription, Genetic


  • Heterogeneous-Nuclear Ribonucleoproteins
  • RNA, Messenger
  • RNA-Binding Proteins