Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 23 (6), 454-63

Testicular Torsion-Detorsion and Potential Therapeutic Treatments: A Possible Role for Ischemic Postconditioning

Affiliations
Review

Testicular Torsion-Detorsion and Potential Therapeutic Treatments: A Possible Role for Ischemic Postconditioning

Shogo Shimizu et al. Int J Urol.

Abstract

Testicular torsion is a common urological emergency among adolescent boys and young men. Rotation of the testis and twisting of the spermatic cord rapidly leads to ischemia, resulting in a loss of germ cells. Thus, prompt diagnosis and urgent surgical intervention are required, but the subsequent release of the torsion induces reperfusion injury, which causes further damage to the ischemic testis. Testicular torsion-detorsion (ischemia-reperfusion) injury triggers the generation of reactive oxygen species, pro-inflammatory cytokines, neutrophil recruitment, lipid peroxidation, anoxia and apoptosis, which carry a significant risk of subsequent infertility. Previously, the effects of numerous pharmacological agents and treatments have been evaluated to prevent testicular ischemia-reperfusion injury in animal models. We propose a new treatment, especially postconditioning, to prevent adverse effects of ischemia-reperfusion injury after testicular torsion-detorsion.

Keywords: ischemia reperfusion; oxidative stress; postconditioning; testis; torsion-detorsion.

Comment in

Similar articles

See all similar articles

Cited by 3 articles

LinkOut - more resources

Feedback