Evaluation of a novel natural drop for treatment of chronic rhinosinusitis without nasal polyps: a single blind randomized trial

Int Forum Allergy Rhinol. 2016 Sep;6(9):943-9. doi: 10.1002/alr.21785. Epub 2016 May 24.


Background: The present study investigated the effectiveness of a Pimpinella anisum-based herbal medicine for treating chronic rhinosinusitis (CRS) without polyps in comparison to fluticasone nasal spray, in a single-blinded randomized trial.

Methods: Patients with CRS without nasal polyps were randomly assigned into 2 treatment groups: individuals in the first group (n = 26) received 2 drops of a P. anisum-based herbal medicine (Sinupim) in each nostril every 12 hours, while those in the second group (n = 22) received 2 puffs of fluticasone nasal spray in each nostril every 12 hours. Both groups used their designated treatments for 4 weeks. Patients were evaluated by the 22-item Sino-Nasal Outcome Test (SNOT-22) at the start of the trial and after the completion of their treatment.

Results: Although both treatments were effective in reducing patients' symptoms, there were significantly better results in the Sinupim group based on the SNOT-22 evaluation. Mean changes in computed tomography (CT) scan scoring in Sinupim and fluticasone groups before and after treatment were 2.22 ± 2.94 and 0.76 ± 1.39, respectively, which was significant within both groups (p < 0.05). Postnasal drip and nasal obstruction were more significantly improved in the Sinupim group.

Conclusion: A P. anisum-based herbal medicine may be an effective treatment for sinusitis without polyps. However, its wide acceptance needs further investigation.

Keywords: Pimpinella anisum; SNOT-22; clinical trial; herbal medicine; sinusitis; treatment.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Chronic Disease
  • Female
  • Fluticasone / therapeutic use
  • Humans
  • Iran
  • Male
  • Medicine, Traditional
  • Middle Aged
  • Paranasal Sinuses / diagnostic imaging
  • Pimpinella*
  • Plant Extracts / adverse effects
  • Plant Extracts / therapeutic use*
  • Plant Oils / adverse effects
  • Plant Oils / therapeutic use*
  • Rhinitis / diagnostic imaging
  • Rhinitis / drug therapy*
  • Seeds
  • Single-Blind Method
  • Sinusitis / diagnostic imaging
  • Sinusitis / drug therapy*
  • Tomography, X-Ray Computed
  • Treatment Outcome
  • Young Adult


  • Plant Extracts
  • Plant Oils
  • almond oil
  • Fluticasone