Impairment of corneal epithelial barrier function in diabetics

Graefes Arch Clin Exp Ophthalmol. 1989;227(2):142-4. doi: 10.1007/BF02169787.


Corneal epithelial permeability was determined using an automatic fluorophotometer in 80 consecutive diabetic patients. The corneal epithelium, which is the most important part of the corneal diffusion barrier, showed a significant increase of permeability to watery, ionic substances (natrium fluorescein). The permeability was increased 5.4 times in comparison with nondiabetic individuals and a distinct correlation of increased permeability with the presence and duration of retinal nonperfusion areas was observed.

MeSH terms

  • Aged
  • Cornea / metabolism*
  • Cornea / physiopathology
  • Diabetes Mellitus / metabolism*
  • Epithelium / metabolism
  • Fluorescein
  • Fluoresceins / pharmacokinetics*
  • Humans
  • Middle Aged
  • Permeability


  • Fluoresceins
  • Fluorescein