Discovery of a highly potent FLT3 kinase inhibitor for FLT3-ITD-positive AML

H Wu; A Wang; Z Qi; X Li; C Chen; K Yu; F Zou; C Hu; W Wang; Z Zhao; J Wu; J Liu; X Liu; L Wang; W Wang; S Zhang; R M Stone; I A Galinsky; J D Griffin; D Weinstock; A Christodoulou; H Wang; Y Shen; Z Zhai; E L Weisberg; J Liu; Q Liu

doi:10.1038/leu.2016.151

Discovery of a highly potent FLT3 kinase inhibitor for FLT3-ITD-positive AML

Leukemia. 2016 Oct;30(10):2112-2116. doi: 10.1038/leu.2016.151. Epub 2016 May 25.

Authors

H Wu^{1

2}, A Wang^{1

2}, Z Qi^{1

3}, X Li^{1

3}, C Chen^{1

3}, K Yu^{1

2}, F Zou^{1

3}, C Hu^{1

2}, W Wang^{1

3}, Z Zhao^{1

3}, J Wu^{1

2}, J Liu^{1

2}, X Liu^{1

2}, L Wang^{1

3}, W Wang^{1

3}, S Zhang^{3

4}, R M Stone⁵, I A Galinsky⁵, J D Griffin⁵, D Weinstock⁵, A Christodoulou⁵, H Wang^{6

7}, Y Shen^{6

7}, Z Zhai^{6

7}, E L Weisberg⁵, J Liu^{1

3}, Q Liu^{1

2

3

8}

Affiliations

¹ High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, China.
² University of Science and Technology of China, Hefei, China.
³ CHMFL-HCMTC Target Therapy Joint Laboratory, Hefei, China.
⁴ Hefei Cosource Medicine Technology Co. LTD., Hefei, China.
⁵ Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
⁶ Department of Hematology, The Second Hospital of Anhui Medical University, Hefei, China.
⁷ Hematology Research Center, Anhui Medical University, Hefei, China.
⁸ Hefei Science Center, Chinese Academy of Sciences, Hefei, China.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Line, Tumor
Drug Discovery*
Humans
Leukemia, Myeloid, Acute / drug therapy*
Leukemia, Myeloid, Acute / pathology
Mice
Protein Kinase Inhibitors / pharmacology*
Protein Kinase Inhibitors / therapeutic use

Substances

Protein Kinase Inhibitors

Publication types

MeSH terms

Substances

Grants and funding