[Anti-wrinkle creams with hyaluronic acid: how effective are they?]

MMW Fortschr Med. 2016 May 25:158 Suppl 4:1-6. doi: 10.1007/s15006-016-8302-1. Epub 2016 May 25.
[Article in German]


Background: Anti-wrinkle creams containing hyaluronic-acid are often advertised as an efficacious option for the treatment of wrinkles and have even been presented as an option equal to some medical procedures in this regard. Evidence from conclusive and systematic research supporting those claims, however, is widely lacking.

Objectives: During this trial we examined whether the daily use of anti-wrinkle creams containing hyaluronic-acid has an influence on the depth of wrinkles as well as skin tightness and elasticity.

Methods: We split up 20 patients into four groups, each of which were assigned an anti-wrinkle cream containing hyaluronic acid for daily use. Four different creams within different price ranges were chosen (Balea, Nivea, Lancôme, Chanel). Before and after the 3 month trial, wrinkle depth was assessed using the PRIMOS(pico) (GFMesstechnik, Teltow, Germany) and skin-tightness and elasticity were evaluated using the Cutometer MP580 (Courage+Khazaka, Cologne, Germany). Additionally, after the trial, questionnaire data on patient satisfaction with their individual product was collected.

Results: The depth of perioral and orbital wrinkles decreased significantly in all groups, with depth reduction ranging between 10% and 20%. Skin-tightness increased significantly in all groups, rising by 13 to 30%. Minimal significant changes in skin-elasticity could only be shown in individual groups.

Conclusions: The regular use of hyaluronic-acid containing anti-wrinkle creams for over 3 months showed clear and positive effects on wrinkle-depth and skin-tightness. Due to the design of the study, however, no clear indication on the efficacy of hyaluronic acid could be shown.

Keywords: PRIMOS; anti-wrinkle cream; cutometer; hyaluronic acid; wrinkles.

Publication types

  • Clinical Study
  • Comparative Study
  • English Abstract

MeSH terms

  • Adult
  • Consumer Behavior
  • Elasticity / drug effects*
  • Female
  • Follow-Up Studies
  • Humans
  • Hyaluronic Acid / administration & dosage*
  • Hyaluronic Acid / economics
  • Middle Aged
  • Skin Aging / drug effects*
  • Skin Cream / administration & dosage*
  • Skin Cream / economics
  • Treatment Outcome


  • Hyaluronic Acid