HOX13 proteins: the molecular switcher in Hoxd bimodal regulation

Genes Dev. 2016 May 15;30(10):1135-7. doi: 10.1101/gad.283598.116.


The striking correlation between the genomic arrangement of Hox genes and their temporal and spatial pattern of expression during embryonic development has been a source of fascination since its discovery. This correspondence has been used as a privileged example in the investigation of the connection between genomic architecture and function. In this issue of Genes & Development, Beccari and colleagues (pp. 1172-1186) make a big step forward in understanding Hox gene regulation during limb development by showing the pivotal role of HOXA13 and HOXD13 proteins in the transition from a proximal to a distal type of Hoxd transcriptional regulation.

Keywords: ankle; polycomb; regulatory landscapes; topologically associating domains (TADs); vertebrate limbs; wrist.

Publication types

  • Comment

MeSH terms

  • Embryonic Development
  • Extremities / embryology*
  • Gene Expression Regulation, Developmental*
  • Genes, Homeobox
  • Homeodomain Proteins / genetics
  • Transcription Factors / genetics


  • Homeodomain Proteins
  • Transcription Factors