Intestinal-type sinonasal adenocarcinomas: The road to molecular diagnosis and personalized treatment

Head Neck. 2016 Oct;38(10):1564-70. doi: 10.1002/hed.24416. Epub 2016 May 25.


Background: Sinonasal intestinal-type adenocarcinomas (ITACs) are epithelial tumors of the nasal cavity and the paranasal sinuses, often related to professional exposure to organic dust, mainly wood or leather. It is a rare cancer. If resectable, surgery is the treatment of choice. Postoperative radiotherapy is often indicated to increase local control. Systemic treatment (chemotherapy, targeted agents, or immunotherapy) of irresectable ITACs and/or metastasized disease is less standardized.

Methods: Articles on ITAC histopathology, molecular profile, and current treatment options of this specific tumor were identified and reviewed, using the electronic databases Pubmed, Medline, Cochrane, and Web of Science.

Results: This article reviews what is currently known on the histopathology, tumorigenesis, molecular characteristics, and standardized treatment options of ITAC.

Conclusion: More translational research is needed to identify druggable targets that may lead to a personalized treatment plan in order to improve long-term outcome in patients with locally advanced and/or metastasized ITAC. © 2016 Wiley Periodicals, Inc. Head Neck 38: First-1570, 2016.

Keywords: gene expression; intestinal-type adenocarcinoma; pathology; sinonasal adenocarcinoma; treatment.

Publication types

  • Review

MeSH terms

  • Adenocarcinoma* / etiology
  • Adenocarcinoma* / pathology
  • Adenocarcinoma* / therapy
  • DNA Mutational Analysis
  • DNA, Neoplasm
  • Dust
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Mutation
  • Nose Neoplasms / etiology
  • Nose Neoplasms / pathology
  • Nose Neoplasms / therapy
  • Paranasal Sinus Neoplasms* / etiology
  • Paranasal Sinus Neoplasms* / pathology
  • Paranasal Sinus Neoplasms* / therapy
  • Prognosis


  • DNA, Neoplasm
  • Dust