Effectiveness of skin absorption of tincture of I in blocking radioiodine from the human thyroid gland

Health Phys. 1989 Jun;56(6):911-4. doi: 10.1097/00004032-198906000-00009.


Topical application of tincture of iodine (I) was found to be effective in blocking the thyroid uptake of orally administered 131I in humans. Abdominal skin application of tincture of I resulted in an approximately 82% reduction in the uptake of 131I by the thyroid gland. The effectiveness varied among individuals and may have depended on the quantity applied and on the application site. In each study group, elevated levels of serum I were observed.

MeSH terms

  • Administration, Cutaneous
  • Adult
  • Humans
  • Iodine / administration & dosage*
  • Iodine / therapeutic use
  • Iodine Radioisotopes / metabolism*
  • Male
  • Middle Aged
  • Skin Absorption*
  • Solutions
  • Thyroid Gland / metabolism*


  • Iodine Radioisotopes
  • Solutions
  • Iodine