Terapeutic Potential of Microencapsulated Sertoli Cells in Huntington Disease

CNS Neurosci Ther. 2016 Aug;22(8):686-90. doi: 10.1111/cns.12569. Epub 2016 May 26.


Introduction: Immune dysfunction, promoted by pro-inflammatory cytokines, plays a pivotal role in neurodegeneration associated with Huntington's disease.

Aims: The aim of this study was to investigate the emerging immunoregulatory and antiinflammatory properties of Sertoli cells in Huntington's disease.

Methods: The experimental R6/2 mouse model of Huntington's disease was treated by a single intraperitoneal injection of microencapsulated prepubertal porcine Sertoli cells and lifespan, motor performance and striatal inflammatory pattern have been evaluated.

Results: The results of this study demonstrated that a single intraperitoneal injection of microencapsulated prepubertal porcine Sertoli cells uniquely improved performances and extended the life expectancy of R6/2 Huntington's disease mice, by immune dysfunction modulation in brain.

Conclusions: This study highlights the immunomodulatory and trophic role of Sertoli cells that could be of help in the treatment of neurodegenerative disorders.

Keywords: Cell transplant; Inflammation; Microcapsules; Motor performance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Newborn
  • Apoptosis / genetics
  • Apoptosis / physiology
  • Corpus Striatum / cytology
  • Cyclooxygenase 2 / metabolism
  • Cytokines / genetics
  • Cytokines / metabolism
  • Disease Models, Animal
  • Drug Compounding / methods*
  • Female
  • Gene Expression Regulation / physiology
  • Humans
  • Huntingtin Protein / genetics
  • Huntingtin Protein / metabolism
  • Huntington Disease / genetics
  • Huntington Disease / mortality
  • Huntington Disease / physiopathology
  • Huntington Disease / surgery*
  • Male
  • Mice
  • Mice, Transgenic
  • Motor Activity / physiology
  • Nitric Oxide Synthase Type II / metabolism
  • Sertoli Cells / physiology*
  • Sertoli Cells / transplantation*
  • Survival Analysis
  • Swine
  • Trinucleotide Repeats / genetics


  • Cytokines
  • HTT protein, human
  • Huntingtin Protein
  • Nitric Oxide Synthase Type II
  • Cyclooxygenase 2