Calicheamicins, a novel family of antitumor antibiotics: taxonomy, fermentation and biological properties

J Antibiot (Tokyo). 1989 Apr;42(4):558-63. doi: 10.7164/antibiotics.42.558.

Abstract

A novel family of antitumor antibiotics, the calicheamicins, were isolated from the fermentation broth of Micromonospora echinospora subsp. calichensis. These antibiotics exhibited significant activity against Gram-positive and Gram-negative bacteria in vitro. Calicheamicin gamma 1I demonstrated antitumor activity against P388 leukemia and B16 melanoma in vivo.

MeSH terms

  • Aminoglycosides*
  • Animals
  • Anti-Bacterial Agents / therapeutic use*
  • Antibiotics, Antineoplastic / biosynthesis*
  • Antibiotics, Antineoplastic / pharmacology
  • Antibiotics, Antineoplastic / therapeutic use
  • Bacteria / drug effects*
  • Culture Media
  • Enediynes
  • Fermentation
  • Leukemia P388 / drug therapy*
  • Leukemia, Experimental / drug therapy*
  • Male
  • Melanoma, Experimental / drug therapy*
  • Mice
  • Micromonospora / classification
  • Micromonospora / growth & development
  • Micromonospora / metabolism*
  • Soil Microbiology

Substances

  • Aminoglycosides
  • Anti-Bacterial Agents
  • Antibiotics, Antineoplastic
  • Culture Media
  • Enediynes
  • calicheamicin gamma(1)I