Metabolic products of microorganisms. 254. Structure of the new nikkomycins pseudo-Z and pseudo-J

J Antibiot (Tokyo). 1989 May;42(5):711-7. doi: 10.7164/antibiotics.42.711.

Abstract

Two new nikkomycins were isolated from the fermentation broth of Streptomyces tendae Tü 901/PF 53+-3. These new metabolites, nikkomycins pseudo-Z (psi-Z,1) and pseudo-J (psi-J, 2) differ from the corresponding nikkomycins Z and J by a C-glycosidic bond between C-5 of uracil and C-1' of 5-amino-5-deoxy-D-allo-furanuronic acid instead of an N-glycosidic bond. The structure elucidation was achieved by two-dimensional NMR techniques and mass spectrometry.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aminoglycosides*
  • Anti-Bacterial Agents*
  • Antifungal Agents*
  • Chemical Phenomena
  • Chemistry, Physical
  • Gas Chromatography-Mass Spectrometry
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Molecular Structure
  • Molecular Weight

Substances

  • Aminoglycosides
  • Anti-Bacterial Agents
  • Antifungal Agents
  • nikkomycin pseudo-Z
  • nikkomycin pseudo-J
  • nikkomycin