Should we still use vitamin A to prevent bronchopulmonary dysplasia?

J Perinatol. 2016 Aug;36(8):581-5. doi: 10.1038/jp.2016.76. Epub 2016 May 26.


Bronchopulmonary dysplasia (BPD) is associated with significant short- and long-term morbidity in preterm infants, and it can be prevented in some infants with vitamin A prophylaxis. Vitamin A, once widely used in neonatal intensive care, was scarce for the last few years, but has become available again at a much higher price, leading to dilemmas about its routine use. In this review we discuss experimental, clinical and socioeconomic evidence related to BPD, and provide a framework for clinicians and policy-makers to evaluate the value of vitamin A treatment and make decisions about its use for prevention of BPD.

Publication types

  • Review

MeSH terms

  • Bronchopulmonary Dysplasia / economics*
  • Bronchopulmonary Dysplasia / prevention & control*
  • Cost-Benefit Analysis
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Infant, Very Low Birth Weight
  • Randomized Controlled Trials as Topic
  • Vitamin A / administration & dosage*
  • Vitamin A / economics*


  • Vitamin A