Electrophysiologist shows a cation channel function of MLKL

Cell Res. 2016 Jun;26(6):643-4. doi: 10.1038/cr.2016.64. Epub 2016 May 27.


Whether mixed lineage kinase domain-like (MLKL) mediates necroptosis by forming ion channel, none-selective pore, or simply by disrupting plasma membrane is unclear. In a paper published in recent issue of Cell Research, Xia et al. showed that MLKL functions as a novel class of cation channel.

Publication types

  • Comment

MeSH terms

  • Apoptosis*
  • Cations
  • Cell Membrane
  • Humans
  • Necrosis
  • Protein Kinases*


  • Cations
  • MLKL protein, human
  • Protein Kinases