Replicating repetitive DNA

Nat Cell Biol. 2016 May 27;18(6):593-4. doi: 10.1038/ncb3367.


The function and regulation of repetitive DNA, the 'dark matter' of the genome, is still only rudimentarily understood. Now a study investigating DNA replication of repetitive centromeric chromosome segments has started to expose a fascinating replication program that involves suppression of ATR signalling, in particular during replication stress.

Publication types

  • Comment

MeSH terms

  • Animals
  • Centromere / metabolism
  • DNA / metabolism
  • DNA Replication*
  • Humans
  • Repetitive Sequences, Nucleic Acid / genetics*
  • Xenopus laevis


  • DNA