Diagnosis and management of invasive candidiasis in the ICU: an updated approach to an old enemy

doi:10.1186/s13054-016-1313-6

Review

. 2016 May 27;20(1):125.

doi: 10.1186/s13054-016-1313-6.

Diagnosis and management of invasive candidiasis in the ICU: an updated approach to an old enemy

Thierry Calandra¹, Jason A Roberts², Massimo Antonelli³, Matteo Bassetti⁴, Jean-Louis Vincent⁵

Affiliations

¹ Infectious Diseases Service, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Rue du Bugnon 46, 1011, Lausanne, Switzerland.
² Burns, Trauma and Critical Care Research Centre, The University of Queensland, Royal Brisbane and Women's Hospital, Butterfield Street, 4029 Herston, Brisbane, Australia.
³ Department of Anesthesiology and Intensive Care Medicine, Catholic University of Rome, A. Gemelli University Hospital, Largo A. Gemelli 8, 00168, Rome, Italy.
⁴ Infectious Diseases Division, Santa Maria Misericordia University Hospital, Piazzale Santa MAria della Misericordia 15, 33100, Udine, Italy.
⁵ Department of Intensive Care, Erasme Hospital, Université libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium. jlvincent@intensive.org.

PMID: 27230564
PMCID: PMC4882871
DOI: 10.1186/s13054-016-1313-6

Free PMC article

Review

Diagnosis and management of invasive candidiasis in the ICU: an updated approach to an old enemy

Thierry Calandra et al. Crit Care. 2016.

Free PMC article

. 2016 May 27;20(1):125.

doi: 10.1186/s13054-016-1313-6.

Authors

Thierry Calandra¹, Jason A Roberts², Massimo Antonelli³, Matteo Bassetti⁴, Jean-Louis Vincent⁵

Affiliations

¹ Infectious Diseases Service, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Rue du Bugnon 46, 1011, Lausanne, Switzerland.
² Burns, Trauma and Critical Care Research Centre, The University of Queensland, Royal Brisbane and Women's Hospital, Butterfield Street, 4029 Herston, Brisbane, Australia.
³ Department of Anesthesiology and Intensive Care Medicine, Catholic University of Rome, A. Gemelli University Hospital, Largo A. Gemelli 8, 00168, Rome, Italy.
⁴ Infectious Diseases Division, Santa Maria Misericordia University Hospital, Piazzale Santa MAria della Misericordia 15, 33100, Udine, Italy.
⁵ Department of Intensive Care, Erasme Hospital, Université libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium. jlvincent@intensive.org.

PMID: 27230564
PMCID: PMC4882871
DOI: 10.1186/s13054-016-1313-6

Abstract

Invasive fungal infections, particularly those caused by Candida species, are not uncommon in critically ill patients and are associated with considerable morbidity and mortality. Diagnosis and management of these infections can be challenging. In this review, we will briefly discuss recent epidemiological data on invasive candidiasis and current diagnostic approaches before concentrating on antifungal treatments.

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References

1. Montagna MT, Caggiano G, Lovero G, De Giglio O, Coretti C, Cuna T, et al. Epidemiology of invasive fungal infections in the intensive care unit: results of a multicenter Italian survey (AURORA Project) Infection. 2013;41:645–53. doi: 10.1007/s15010-013-0432-0. - DOI - PMC - PubMed
1. Burghi G, Lemiale V, Seguin A, Lambert J, Lacroix C, Canet E, et al. Outcomes of mechanically ventilated hematology patients with invasive pulmonary aspergillosis. Intensive Care Med. 2011;37:1605–12. doi: 10.1007/s00134-011-2344-8. - DOI - PubMed
1. Mean M, Marchetti O, Calandra T. Bench-to-bedside review: Candida infections in the intensive care unit. Crit Care. 2008;12:204. doi: 10.1186/cc6212. - DOI - PMC - PubMed
1. Marchetti O, Bille J, Fluckiger U, Eggimann P, Ruef C, Garbino J, et al. Epidemiology of candidemia in Swiss tertiary care hospitals: secular trends, 1991–2000. Clin Infect Dis. 2004;38:311–20. doi: 10.1086/380637. - DOI - PubMed
1. Vincent JL, Rello J, Marshall J, Silva E, Anzueto A, Martin CD, et al. International study of the prevalence and outcomes of infection in intensive care units. JAMA. 2009;302:2323–9. doi: 10.1001/jama.2009.1754. - DOI - PubMed

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[1] Montagna MT, Caggiano G, Lovero G, De Giglio O, Coretti C, Cuna T, et al. Epidemiology of invasive fungal infections in the intensive care unit: results of a multicenter Italian survey (AURORA Project) Infection. 2013;41:645–53. doi: 10.1007/s15010-013-0432-0. - DOI - PMC - PubMed

[2] Montagna MT, Caggiano G, Lovero G, De Giglio O, Coretti C, Cuna T, et al. Epidemiology of invasive fungal infections in the intensive care unit: results of a multicenter Italian survey (AURORA Project) Infection. 2013;41:645–53. doi: 10.1007/s15010-013-0432-0. - DOI - PMC - PubMed

[3] Burghi G, Lemiale V, Seguin A, Lambert J, Lacroix C, Canet E, et al. Outcomes of mechanically ventilated hematology patients with invasive pulmonary aspergillosis. Intensive Care Med. 2011;37:1605–12. doi: 10.1007/s00134-011-2344-8. - DOI - PubMed

[4] Burghi G, Lemiale V, Seguin A, Lambert J, Lacroix C, Canet E, et al. Outcomes of mechanically ventilated hematology patients with invasive pulmonary aspergillosis. Intensive Care Med. 2011;37:1605–12. doi: 10.1007/s00134-011-2344-8. - DOI - PubMed

[5] Mean M, Marchetti O, Calandra T. Bench-to-bedside review: Candida infections in the intensive care unit. Crit Care. 2008;12:204. doi: 10.1186/cc6212. - DOI - PMC - PubMed

[6] Mean M, Marchetti O, Calandra T. Bench-to-bedside review: Candida infections in the intensive care unit. Crit Care. 2008;12:204. doi: 10.1186/cc6212. - DOI - PMC - PubMed

[7] Marchetti O, Bille J, Fluckiger U, Eggimann P, Ruef C, Garbino J, et al. Epidemiology of candidemia in Swiss tertiary care hospitals: secular trends, 1991–2000. Clin Infect Dis. 2004;38:311–20. doi: 10.1086/380637. - DOI - PubMed

[8] Marchetti O, Bille J, Fluckiger U, Eggimann P, Ruef C, Garbino J, et al. Epidemiology of candidemia in Swiss tertiary care hospitals: secular trends, 1991–2000. Clin Infect Dis. 2004;38:311–20. doi: 10.1086/380637. - DOI - PubMed

[9] Vincent JL, Rello J, Marshall J, Silva E, Anzueto A, Martin CD, et al. International study of the prevalence and outcomes of infection in intensive care units. JAMA. 2009;302:2323–9. doi: 10.1001/jama.2009.1754. - DOI - PubMed

[10] Vincent JL, Rello J, Marshall J, Silva E, Anzueto A, Martin CD, et al. International study of the prevalence and outcomes of infection in intensive care units. JAMA. 2009;302:2323–9. doi: 10.1001/jama.2009.1754. - DOI - PubMed

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Diagnosis and management of invasive candidiasis in the ICU: an updated approach to an old enemy

Affiliations

Diagnosis and management of invasive candidiasis in the ICU: an updated approach to an old enemy

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