DNA-sequence-specific erasers of epigenetic memory

Nat Genet. 2016 May 27;48(6):591-2. doi: 10.1038/ng.3579.


How epigenetic regulators find their specific targets remains a challenging question. Two parallel studies show that REF6, a plant H3K27me3 demethylase, binds a specific DNA motif via its zinc-finger domains and recruits the SWI/SNF-type ATPase BRAHMA, demonstrating a sequence-specific recruitment mechanism for a chromatin-modifying complex.

Publication types

  • Review
  • Comment

MeSH terms

  • Arabidopsis / genetics
  • Arabidopsis Proteins / genetics
  • DNA / genetics*
  • Epigenesis, Genetic*
  • Transcription Factors / genetics


  • Arabidopsis Proteins
  • REF6 protein, Arabidopsis
  • Transcription Factors
  • DNA