Pyristriatins A and B: Pyridino-Cyathane Antibiotics from the Basidiomycete Cyathus cf. striatus
- PMID: 27231731
- DOI: 10.1021/acs.jnatprod.6b00194
Pyristriatins A and B: Pyridino-Cyathane Antibiotics from the Basidiomycete Cyathus cf. striatus
Abstract
Two novel pyridino-cyathane diterpenoids, pyristriatins A and B (1 and 2), together with striatin C (3) were isolated from cultures of Cyathus cf. striatus, a basidiomycete that was found during a field trip in northern Thailand. The pyristriatins showed antimicrobial effects against Gram-positive bacteria and fungi. The isolation, structure elucidation, relative configuration, and biological and cytotoxic activity are described. Their structures were assigned by HRMS and NMR spectroscopy. We also describe the first 2D NMR assignment of striatin C. Pyristriatins A and B are the first cyathane natural products featuring a pyridine ring.
Similar articles
-
Striatoids A-F, Cyathane Diterpenoids with Neurotrophic Activity from Cultures of the Fungus Cyathus striatus.J Nat Prod. 2015 Apr 24;78(4):783-8. doi: 10.1021/np501030r. Epub 2015 Mar 6. J Nat Prod. 2015. PMID: 25746852
-
Three new cyathane diterpenoids from the medicinal fungus Cyathus africanus.J Asian Nat Prod Res. 2015 May;17(5):541-9. doi: 10.1080/10286020.2015.1043900. Epub 2015 May 29. J Asian Nat Prod Res. 2015. PMID: 26022233
-
Production of bioactive cyathane diterpenes by a bird's nest fungus Cyathus gansuensis growing on cooked rice.Food Chem. 2014;152:169-76. doi: 10.1016/j.foodchem.2013.11.137. Epub 2013 Nov 28. Food Chem. 2014. PMID: 24444922
-
Structure Diversity, Synthesis, and Biological Activity of Cyathane Diterpenoids in Higher Fungi.Curr Med Chem. 2015;22(19):2375-91. doi: 10.2174/0929867322666150521091333. Curr Med Chem. 2015. PMID: 25994862 Review.
-
Cyathane Diterpenes from Cultures of the Bird's Nest Fungus Cyathus hookeri and Their Neurotrophic and Anti-neuroinflammatory Activities.J Nat Prod. 2019 Jun 28;82(6):1599-1608. doi: 10.1021/acs.jnatprod.9b00091. Epub 2019 Jun 18. J Nat Prod. 2019. PMID: 31244147 Review.
Cited by
-
A Decade of Antifungal Leads from Natural Products: 2010-2019.Pharmaceuticals (Basel). 2019 Dec 12;12(4):182. doi: 10.3390/ph12040182. Pharmaceuticals (Basel). 2019. PMID: 31842280 Free PMC article. Review.
-
New nematicidal and antimicrobial secondary metabolites from a new species in the new genus, Pseudobambusicola thailandica.MycoKeys. 2018 Mar 22;(33):1-23. doi: 10.3897/mycokeys.33.23341. eCollection 2018. MycoKeys. 2018. PMID: 29681740 Free PMC article.
-
Antifungal activity of dendritic cell lysosomal proteins against Cryptococcus neoformans.Sci Rep. 2021 Jun 30;11(1):13619. doi: 10.1038/s41598-021-92991-6. Sci Rep. 2021. PMID: 34193926 Free PMC article.
-
Ijuhya vitellina sp. nov., a novel source for chaetoglobosin A, is a destructive parasite of the cereal cyst nematode Heterodera filipjevi.PLoS One. 2017 Jul 12;12(7):e0180032. doi: 10.1371/journal.pone.0180032. eCollection 2017. PLoS One. 2017. PMID: 28700638 Free PMC article.
-
Akanthopyrones A-D, α-Pyrones Bearing a 4-O-Methyl-β-d-glucopyranose Moiety from the Spider-Associated Ascomycete Akanthomyces novoguineensis.Molecules. 2017 Jul 18;22(7):1202. doi: 10.3390/molecules22071202. Molecules. 2017. PMID: 28718819 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases
