Malignant pleural mesothelioma: initial experience in integrated (18)F-FDG PET/MR imaging

Clin Imaging. Sep-Oct 2016;40(5):956-60. doi: 10.1016/j.clinimag.2016.05.001. Epub 2016 May 11.

Abstract

Purpose: This study aims to compare staging results of (18)F-FDG PET/computed tomography (CT) and integrated PET/magnetic resonance (MR) in malignant pleural mesothelioma (MPM) patients and to investigate a potential apparent diffusion coefficient (ADC)/SUV correlation.

Materials and methods: Six patients with MPM underwent (18)F-FDG PET/CT and PET/MR including diffusion-weighted imaging. Thoracic TNM staging was performed for both modalities. SUV and ADC were assessed in therapy-naive pleural lesions.

Results: In thoracic TNM staging, no differences were found between PET/CT and PET/MR. An inverse correlation was observed between SUVmean and ADCmin (r=-0.63, P=.002).

Conclusion: MPM can be staged using PET/MR. The inverse correlation ADC/SUV indicates that future research on multiparametric therapy response evaluation may be warranted.

Keywords: DWI; MPM; Mesothelioma; PET/CT; PET/MR; PET/MRI.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Female
  • Fluorodeoxyglucose F18
  • Humans
  • Lung Neoplasms / diagnosis
  • Lung Neoplasms / diagnostic imaging*
  • Lung Neoplasms / pathology
  • Magnetic Resonance Imaging
  • Male
  • Mesothelioma / diagnosis
  • Mesothelioma / diagnostic imaging*
  • Mesothelioma / pathology
  • Mesothelioma, Malignant
  • Multimodal Imaging
  • Neoplasm Staging
  • Positron Emission Tomography Computed Tomography
  • Predictive Value of Tests

Substances

  • Fluorodeoxyglucose F18