Helminths and Intestinal Flora Team Up to Improve Gut Health

Trends Parasitol. 2016 Sep;32(9):664-666. doi: 10.1016/j.pt.2016.05.006. Epub 2016 May 24.


Inflammatory bowel diseases (IBD) are associated with impaired intestinal barrier function, chronic inflammation, and microbial dysbiosis. In a recent publication in Science, Ramanan et al. used murine and human studies to demonstrate that infections with gastrointestinal helminths can protect against IBD by provoking immune responses that alter the balance of commensal and pathogenic bacteria in the intestine.

Keywords: helminth; hygiene hypothesis; inflammatory bowel disease.; microbiota.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Gastrointestinal Microbiome / physiology*
  • Helminths / immunology
  • Humans
  • Inflammation / immunology
  • Inflammatory Bowel Diseases / immunology
  • Inflammatory Bowel Diseases / microbiology
  • Inflammatory Bowel Diseases / parasitology*
  • Inflammatory Bowel Diseases / prevention & control*
  • Intestines / microbiology*
  • Intestines / parasitology*
  • Mice