Novel Therapies for the Treatment of Central Sleep Apnea

Shahrokh Javaheri; Robin Germany; John J Greer

doi:10.1016/j.jsmc.2016.01.004

Novel Therapies for the Treatment of Central Sleep Apnea

Sleep Med Clin. 2016 Jun;11(2):227-39. doi: 10.1016/j.jsmc.2016.01.004.

Authors

Shahrokh Javaheri¹, Robin Germany², John J Greer³

Affiliations

¹ Bethesda North Hospital, 10535 Montgomery Road, Suite 200, Cincinnati, OH 45242, USA. Electronic address: shahrokhjavaheri@icloud.com.
² Section of Cardiology, University of Oklahoma College of Medicine, Oklahoma City, OK, USA.
³ University of Alberta, Edmonton, Alberta, Canada.

PMID: 27236059
DOI: 10.1016/j.jsmc.2016.01.004

Abstract

Neurophysiologically, central apnea is due to a temporary cessation of respiratory rhythmogenesis in medullary respiratory networks. Central apneas occur in several disorders and result in pathophysiological consequences, including arousals and desaturation. The 2 most common causes in adults are congestive heart failure and chronic use of opioids to treat pain. Under such circumstances, diagnosis and treatment of central sleep apnea may improve quality of life, morbidity, and mortality. This article discusses recent developments in the treatment of central sleep apnea in heart failure and opioids use.

Keywords: Adaptive servo ventilators; Ampakines; Apnea; CPAP; Congestive heart failure; Opioids.

Publication types

Review

MeSH terms

Humans
Sleep Apnea, Central / therapy*