An Autoimmune Polyglandular Syndrome Complicated With Celiac Disease and Autoimmune Hepatitis

Ann Hepatol. Jul-Aug 2016;15(4):588-91.

Abstract

Autoimmune polyglandular syndrome (APS) is a combination of different autoimmune diseases. The close relationship between immune-mediated disorders makes it mandatory to perform serological screening periodically in order to avoid delayed diagnosis of additional autoimmune diseases. We studied a patient with type 1 diabetes (T1D) who later developed an autoimmune thyroid disease (ATD) and was referred to our hospital with a serious condition of his clinical status. The patient was suffering from an advance stage of celiac disease (CD), the delay in its diagnosis and in the establishment of a gluten-free dietled the patient to a severe proteincalorie malnutrition. Later, the patient developed an autoimmune hepatitis (AIH). We consider that clinical deterioration in patients with APS should alert physicians about the possible presence of other immune-mediated diseases. Periodic screening for autoantibodies would help to prevent delayed diagnosis and would improve patient's quality of life.

Publication types

  • Case Reports

MeSH terms

  • Autoantibodies / immunology
  • Celiac Disease / complications
  • Celiac Disease / diagnosis*
  • Celiac Disease / diet therapy
  • Celiac Disease / immunology
  • Delayed Diagnosis
  • Diabetes Mellitus, Type 1 / complications
  • Diabetes Mellitus, Type 1 / diagnosis*
  • Diabetes Mellitus, Type 1 / immunology
  • Diet, Gluten-Free
  • Hepatitis, Autoimmune / complications
  • Hepatitis, Autoimmune / diagnosis*
  • Hepatitis, Autoimmune / immunology
  • Humans
  • Male
  • Middle Aged
  • Polyendocrinopathies, Autoimmune / complications
  • Polyendocrinopathies, Autoimmune / diagnosis*
  • Polyendocrinopathies, Autoimmune / immunology
  • Protein-Energy Malnutrition / diagnosis*
  • Protein-Energy Malnutrition / etiology
  • Thyroiditis, Autoimmune / complications
  • Thyroiditis, Autoimmune / diagnosis*
  • Thyroiditis, Autoimmune / immunology

Substances

  • Autoantibodies