The human gut microbiome impacts health and disease

Abstract

The human gut microbiome can now be characterized in unprecedented detail by an approach based on high-throughput sequencing of total stool DNA, that we name quantitative metagenomics. Central to the approach is a catalog that lists all the genes of intestinal microbes that are known - 9.9 millions, identified by the analysis of 1267 stool samples. Beyond the gene list, genetic units that carry them begun to be known; many of these correspond to bacterial species that were never isolated and cultured yet. Quantitative metagenomics allows developing powerful algorithms to diagnose a disease, monitor patients and identify individuals at risk to progress towards a disease. This lays ground for developing new approaches to better restore and even preserve the health by modulation of the altered microbiome, which contributes to promote or aggravate a disease.

Keywords: Catalogue des gènes microbiens; Chronic disease prevention; Communautés microbiennes; Dysbiose; Dysbiosis; Microbial communities; Microbial gene catalog; Métagénomique quantitative; Prévention des maladies chroniques; Quantitative metagenomics.