Sarcomeres and Cardiac Growth: Tension in the Relationship

Trends Mol Med. 2016 Jul;22(7):530-533. doi: 10.1016/j.molmed.2016.05.001. Epub 2016 May 26.

Abstract

Genetic mutations in the cardiomyocyte contractile apparatus cause aberrant cardiac growth categorized morphologically as hypertrophic or dilated. A recent study leverages an array of mutant mouse models to extrapolate a new integrated parameter: the myofilament 'tension index', which predicts patterns of cardiac growth resulting from individual sarcomeric mutations. These findings may inform genotype-specific therapies.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Animals
  • Cardiomyopathy, Dilated / genetics*
  • Cardiomyopathy, Dilated / pathology
  • Cardiomyopathy, Hypertrophic / genetics*
  • Cardiomyopathy, Hypertrophic / pathology
  • Genotype
  • Heart / growth & development
  • Humans
  • Mice
  • Muscle Proteins / genetics*
  • Mutation*
  • Myocardium / metabolism
  • Myocardium / pathology*
  • Myocytes, Cardiac / metabolism
  • Myocytes, Cardiac / pathology*
  • Sarcomeres / genetics*
  • Sarcomeres / pathology

Substances

  • Muscle Proteins